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Thrombin is a trypsin-like serine protease which is best known for its role in blood clotting. In humans, the F2 gene codes for prothrombin, which is also known as Coagulation Factor II. Clevage of prothrombin to form activated α-thrombin is a key step in the final common pathway of blood clotting, because clevage by thrombin activates several factors in blood clotting, especially fibrin, factor XIII, and protein C.

Structure
Thrombin is comprised of two chains, often referred to as the short chain and the long chain. All known functional epitopes are found on the long chain. There is one active site, which in the case of 1ppb is occupied with D-Phe-Pro-Arg chloromethylketone. Additionally, there are three structural disulfide bonds.

α-Thrombin

 * 1ppb
 * 1uma
 * 1de7

Prothrombin

 * 2afq

External Resources

 * Thrombin at Wikipedia
 * Serine protease at Wikipedia
 * Fibrin Glue at Wikipedia
 * Coagulation (blood clotting) at Wikipedia
 * Hemophilia at Wikipedia

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